Why should you? It will soon be boring again, so get going while you can.īy observing the movements of the planets, astrology can reveal certain things about what will happen to Gemini during the year – at least some of the most significant events.Mercury Retrograde and What it Means for You You’ll have a hard time standing still any amount of time. ![]() ![]() You get and exchange ideas, you have fun, you are stimulated way beyond normal. That’s even more of a boost for every Gemini, again especially for those born around that date. So, take a chance to have a great experience that day.Īnd then on the 7th of July, Mercury forms a conjunction with the sun. This is mainly true for those born on that date and the days surrounding it, but every Gemini should feel at least some of it. Things go just as you like, and effortlessly too. That gives the nice Venus influence a significant boost, pleasant enough to be a memorable sensation. On June 7 of 2016, Venus forms a conjunction with the sun in Gemini. Since Mercury enters Gemini shortly before Venus exits, together they make for quite an agreeable start of the 2016 summer. So, its presence in Gemini will bring good humor and a general feeling of well-being, together with an increased lust to be playfully creative. Things tend to run more smoothly when Venus is around, and they lead to better results than might have been expected. Venus brings ease and pleasure, also a creative mood. It comes to the sign on the 24th of May 2016. Venus enters Gemini earlier than Mercury does. Be sure to make good use of the short time and enjoy it. You will definitely have an unusual lot of fun those weeks. It brings a boost of intellectual activities and interactions with people. A mere two weeks.ĭuring that time, though, it livens things up quite a bit for every Gemini. Mercury enters Gemini on the 13th of June 2016, to stay there only until the end of the month. Mercury is in Gemini for a couple of stimulating weeks. And not even then is its role other than a neutral magnifier.īut Mercury is particularly significant in Gemini, since it is the ruler of that Zodiac sign. The transit sun is not astrologically significant on its own, only when forming conjunctions or other aspects with other planets. They are companions to the sun, following its path around the Zodiac. That is something to look forward to.īut as I said, until then nothing much to talk about.Īs for 2016, then, the only thing to look forward to is the annual visit of Mercury and Venus. ![]() The summer of the following year, Uranus reaches Gemini. A major planet will not come until the end of May 2024, when Jupiter returns to Gemini. This will not change until April 2017, when Mars reenters Gemini for a month or so of some adventure. The complete 2016 world horoscope chart, based on Greenwich at New Year 2016. The same time Mars entered Gemini to spend a month and a half there, causing the excitement and intensified activity typical for Mars.īut since then nothing at all spectacular. The last time a major planet was in Gemini was the summer of 2013, when Jupiter left the sign after staying a year in it, bringing a lot of luck and opportunities. Your personal horoscope chart contains a lot more, so you can still have exciting times in 2016 because of transit aspects to planets and other points in your own complete horoscope.īut here, I speak about Gemini in general, from what happens to that sign only. Notice that this is the situation for Gemini in general, considering only the sun sign. That is because no major planets pass through Gemini during this long period. ![]() So was 2015 and so will several years ahead be. I’m sorry to say that 2016 is likely to be a dull year for Gemini.
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The binding of the S1P receptor on T lymphocytes blocks their migration from the lymph nodes to the CNS. It was indicated as a DMT for the treatment of adult patients and pediatric patients of 10 years of age and above with RRMS to reduce the frequency of relapses and to delay the progression of disability. Fingolimod, a first-in-class Sphingosine-1-Phosphate (S1P) receptor modulator was the first oral drug to be approved for the treatment of MS. As the number of treatment-related infections is increasing, careful diagnosis of MS patients presenting with new neurological symptoms is essential. Most drugs used in MS treatment are linked to an increased risk of infection to varying degrees, depending on their mechanism of action. Currently approved Disease-Modifying Therapies (DMTs) are immunomodulatory or immunosuppressive drugs that significantly, although variably, reduce the frequency of attacks of the relapsing forms of the disease. This chronic inflammatory condition of the CNS is caused by an autoimmune process, leading to multifocal demyelination and axonal loss, mostly in the white matter, but importantly also in the grey matter of both brain and spinal cord. Multiple Sclerosis (MS), the most common neurological disability, is an autoimmune disorder that affects the Central Nervous System (CNS) and often leads to severe physical or cognitive dysfunctions in young adults. Keywords: Fingolimod Cryptococcal meningitis Multiple sclerosis Disease-modifying therapiesĪbbreviations: MS: Multiple Sclerosis CNS: Central Nervous System DMTS: Disease-Modifying Therapies S1P: Sphingosine-1-Phosphate RRMS: Relapsing-Remitting MS PML: Progressive Multifocal Leukoencephalopathy HSV: Herpes Simplex Virus CSF: Cerebrospinal Fluid MRI: Magnetic Resonance Imaging MRC: Medical Research Council CRP: C-Reactive Protein INF: Interferon AIDS: Acquired Immunodeficiency Syndrome IRIS: Immune Reconstitution Inflammatory Responses In this report, we present the treatment problems that arise in patients with MS treated with immunomodulation therapy who develop an opportunistic infection. Recommendations for the surveillance of opportunistic infections are increasingly needed as more patients are treated with immunomodulation therapy for longer durations and at older ages. Conclusion: Some agents carry a risk of opportunistic and life-threatening infections. In the control examination, CSF culture showed no microbial growth and MRI showed an improvement in the radiological condition. The patient's general and neurological condition gradually improved. Amphotericin B with fluconazole were included and fingolimod was discontinued. ![]() Cryptococcal meningitis has been recognized. Finally, a culture of the CSF showed Cryptococcus neoformans growth. In Magnetic Resonance Imaging (MRI) strengthening of the meninges of the brain and cerebellum was visualized. Examination of Cerebrospinal Fluid (CSF) showed intensified cytosis, increased protein level and decreased glucose level. The results of laboratory and imaging tests were inconclusive. She has been treated with fingolimod science 2013. She was reported to the hospital emergency department due to headache with accompanying low-grade fever. Case presentation: We present a 46-year old woman with RRMS on fingolimod therapy with a rare case of cryptococcal meningitis. Early diagnosis and appropriate treatment are essential to improve prognosis and reduce mortality in these cases. Post-marketing experience has documented several cases of cryptococcal meningitis and disseminated cryptococcosis. ![]() ![]() However, fingolimod may be associated with a higher risk of several different opportunistic infections, including cryptococcosis. Integrated analysis of the long-term safety studies results showed that there was no overall increase in the risk of infection in patients treated with fingolimod compared to patients treated with placebo. Background: Fingolimod is an oral medication approved by the Food and Drug Administration for the treatment of Relapsing Remitting Multiple Sclerosis (RRMS). ![]() George Jones' 1983 version of the song was included on his album Shine On, and reached number 2 on the Hot Country Singles chart. chris stapleton tennessee whiskey lyrics : i used to spend my nights out in a barroom liquor was the only love ive known but you rescued me from reachin. Originally Tennessee Whiskey is recorded by American country music artist David Allan Coe for his album of the same name Tennessee Whiskey, whose version peaked at number 77 on the Billboard Hot Country Singles chart in 1981. Stapleton's version of the song has been certified 6× Platinum by the Recording Industry Association of America (RIAA). Tennessee Whiskey is a song covered by American singer-songwriter Chris Stapleton, whose breakout performance of the song at the Country Music Association (CMA) Awards with Justin Timberlake propelled the song to a greater level of popularity. ![]() So if you like it, just download it here. ![]()
![]() You won't have to worry about his shadowy comrades, either, as they'll not only fall easily, but will drop Potions and Ethers for you. He and his cohorts will likely kill you and/or your friends more than once, and you'll want to Raise your party members-or pick up a nearby Phoenix Down, if one is available-whenever this happens. ![]() Once you've got the timing down, you too can move in and give the ol' scholar a few whacks, but take care, as his knock-back attacks may send you into a flying face-plant. Meanwhile, your friends will give him a good beating. Since he'll only try to cast things on the character you're controlling (like practically every enemy), you can lead his target away from your companions by running around the room in wide circles. ![]() Mime - Morph - Sense - Slash-All - W-Item - W-Magic - W-SummonĪbsorb - Card - Darkside - Devour - Doom - Draw - Kamikaze - LV Down - LV Up - Mad Rush - MiniMog - TreatmentĪrmor - Sentinel - Shield - Skill - Special - Trigger - WeaponĪrcana - Assault - Berserk - Blue Bullet - Bribe - Bushido - Charon - Crush - Cutlery - Dance - Dextral Arts - Fallalery - Fiend Hunter - Finale - Flimflam - Flurry - Fright - Gamble - Ghiki - Great Whirl - Gunplay - Homing Ray - Howl - HP Repair - Instinct - Kogoro - Kupo! - Left Stigma - Left Pistilplay - Machinations - Mettle - MP Absorb - MP Repair - Mug - Nab Gil - Psionics - Reboot - Right Stigma - Right Pistilplay - Sentinel - Sing - Sinistral Arts - Spare Change - Smash - Stamina - Stash - Sword Dance - Tantalize - Teleport - Throttle - Trigger Happy - Wildcat - Vajra - Vigor - ZantetsuĪimed Shot - Arithmeticks - Fundaments - Geomancy - Holy Sword - Huntcraft - Iaido - Limit - Mettle - Mystic Arts - Nether Mantra - Piracy - Sky Mantra - Speechcraft - Unyielding BladeĪdvanced Law - Alchemy Tech - Battle Tech - Charge - Corner - Dragon Tech - Fighter Tech - Hermetics - Hunt - Lunge Tech - Monk Tech - Morph - Ninja Skill - Pandora - Prayer - Phantasm Tech - Rune - Sacred Tech - Sagacity Skill - Sharpshoot - Spellblade Tech - Spirit Magic - Stuntįinal Fantasy Tactics A2: Grimoire of the RiftĪcrobatics - Assassination - Astutia - Ballistics - Beast Lore - Blade Arts - Brutality - Calling - Cannonry - Chococraft - Clockwork - Devastation - Discipline - Dragon Soul - Elemental Magick - Fencing - Feralism - High Magick - Illusion - Instinct - Intercession - Lore - Onslaught - Piracy - Precision - Pugilism - Reconnaissance - Sacred Blade - Sagacity - Savagery - Sharpshooting - Sleight of Hand - Sparring - Survivalism - Thievery - Trapping - Wardingīack Up - Battle Arts - Boost Element - Chain Magic - Clarity - Dragon Arts - Dark Blade - Holy Blade - Memorandom - Pickpocket - Res.Despite its intimidating beginnings, this fight is a lot less challenging than you'd expect, due to your foe's love of magic. Advance - Analyze - Boost - Cheer (NES) - Peep (NES) - Retaliate - Scare (NES) - Sing - Souleater - Studyįinal Fantasy IV: The Complete CollectionĪnalyze - Bless - Bluff - Brace - Cry - Chant - Curse - Deadly - Double Jump - Eye Gouge - Inferno - Phoenix - Plunder - Regen - Requiem - Return - Salve - Tsunami - Twincast - Upgrade - WhirlwindĪnalyze - Awaken - Band - Big Throw - Cover Counter - Human Kite - Illusions - Jive - Piercing Sight - Pressure - Risk Strike - Shuriken - Taunt - TenketsuĪnimals - Bladeblitz - Calm - Condemn - Check - Combine - Dark Arts - Drink - Finisher - Flirt - Gaia - Guard - Iainuki - Image - Lance - Mineuchi - Oath - Open Fire - Predict - Scan - Smoke - Zeninageīlitz - Leap - Lore - Magitek - Rage - Runic - Possess - Shock - Sketch - Slot - Tools - TranceĢx-Cut - 4x-Cut - Coin - D.blow - E.Skill - Flash - Manip. ![]() Here’s the bottom line: the HELIO LX is one of the best portable showers out there because of its light weight and supreme packability. This however we are not going to mark down as a fault, because it was so obviously in service of the overall packability of this product that we don’t think an electric pump will make this any better. It also means that you have to use the included foot pump to get the water to come out. Fortunately, this is probably what the HELIO LX is best at. Number one, there is no way to heat up the water with electricity, so you will have to rely on the units natural ability to use ambient warmth and sunlight in order to heat the water up. So there are two basic deficiencies with this shower that you will have to get over right off the bat. How does Nemo make their product so light? Well, they’ve decided to scrap two of the most popular on-board features in camping showers: 1.) The Heating Element, and 2.) The electric H20 pump. The Nemo HELIO LX Pressure shower is just over 2 pounds, which means that your water bottle is likely putting more weight into your pack than this shower is. Here is a portable camping shower for the ultralight inclined. While the initial iterations of ZODI’s camping shower featured a 20 minute heating time, this new model gets it down to a brisk 5 minutes, which is perhaps the very fastest heating time on the entire review. After all, wouldn’t you want to know the temperature of the water before you pump it directly to your skin? This is something that we have only seen once or twice on a camping shower before, though it seems like one of the first things you would add if you were building your own. However, at 11.8 LBS, it is not exactly meant for the ultralight hikers. This is why the 3 Gallon capacity is somewhat reduced compared to other camp showers. ![]() While most long distance hikers either use the cold river or forego bathing altogether, a select few have adopted this clever new piece of technology from ZODI, a small gear manufacturer that is changing the way we think of portable showers.Ī basic overview: The ZODI camping shower is a bit different from the others on our list in that it is specifically designed to be lightweight and compact to make it a good option for backpacking and long distance hiking. Unfortunately, there isn’t much chance that you are going to find a shower-house way out in the backcountry. We don’t think it would be exaggerating to say that there is simply nothing in the whole world that is better than climbing into a long, hot shower after a solid 10 mile hike. We can truly see why this has become one of the most popular camping showers of 2023. ![]() This is a great little shower with multiple reservoir sizes, and each one of them is on the less expensive side of its product class. We took a hands-on look at the Big Kahuna ourselves to see how it stacked up against our famously rigorous review standards, and the result was that just about everything we had read was confirmed. In addition, heating times are pretty quick, and there is the option of upgrading the heating element for an additional charge if you are interested in heating the water even faster. The internal pump provides an impressive amount of water pressure, especially for a 12V power source. The consensus among portable shower user reviews is that the BIG KAHUNA is one of the most reliable and simplistically designed portable camping shower that you can find anywhere. We’re taking a peek at the 8 Best Camping Showers of the 2023 season, and if you stick around after that, you might learn a thing or two about how exactly these things work and how you might go about finding one for yourself. While the best camping showers feature things like internal heating elements and rechargeable pumps, the most simplistically designed camping showers can still provide you with something that is all too rare in the wild: a downward falling stream of clean, cleansing water. Unfortunately, the last time we checked there weren’t that many shower houses out in the wilderness, where the best adventures tend to happen.Īccording to the World Panel, Americans average 7 showers per week, so why wouldn’t we want one when we were away from home, too? Portable Camping Showers make this a possibility, because last time we checked, there weren’t a whole lot of shower houses out in the great wilderness. It doesn’t matter if you are hiking 5 miles out to your favorite lake, or a 40 mile trek around the mountain, there is nothing quite like a good refreshing shower after a day (or days) of rigorous adventure. Are you seeking the best camping shower for everyday adventures? We researched more than 50 models available in 2023 and tested them side-by-side. ![]() Gone were superfluous drills, a laborious check-in system for attendees, and fancy equipment. ![]() The first several classes of my new venture were poorly attended, and my decision to start my own bootcamp looked like a failed gamble.īut I stuck with it and stripped away all “the noise”. KISS and Customers: Working BackwardsĪ key tenet of KISS is that you must obsess over the customer and make decisions that benefit these stakeholders.īy working backwards from what customers need and want, one can simplify and remove policies, software layers, work-flows, or even iconography that are incongruent with earning customer trust. Should I continue coaching in an inefficient and less effective manner, or take a chance, and start my own fitness course? When my idea was rejected, I was faced with a dilemma. And I suggested that we expand our class offerings to additional weekday evenings. The class, though popular, had design problems.įor example, it was impractical to coach over 70 people at the same time. As time progressed, the founder of the fitness program asked me to assist him in instructing the workouts. While living in Australia I joined an exercise cross-training class to maintain my fitness. ![]() It also shows that KISS can apply to many domains in our lives – not just building technical products. How this class came about and my role in developing it into a small side business underscores my love of coaching and building. In the summer of 2014, I started a bootcamp exercise class called “Fun Social Exercise”. I want to use examples from my time as a builder and entrepreneur to share my perspectives with you.īy sharing these lessons, I hope that you can best leverage the KISS principle in your work. There are few commercial, intellectual, or technical reasons to make things complicated when simplicity can help you design, launch, scale, and learn faster. I have also seen how complex standards have been refined so that the design is left simpler and stronger as a result. Having built and launched products, I have witnessed firsthand when good ideas are made irrelevant because of product complexity and the ensuing product debt that follows. When building a product, designing a website, creating an app, or engineering a block of code, strive for simplicity. And that kind of carried on in the Halloween episode and just really grew from there.The KISS principle (or Keep It Simple, Stupid) states that most systems work best if they are kept simple rather than made overly complicated. I think that was the moment where it was like, ‘Oh wait there is a way to do this, he can still be insufferable but he can be well-meaning at the same time.’ He can have moments where right when you think he’s gonna be an idiot, he actually does something smart or has a lucid moment where you kind of vest interest in him. “That was kind of this weird turning point where it was harder to cut to people laughing at him because we’re all going, ‘Oh God, this poor guy,’ because he got roped into getting this condo he’s gonna buy and stuff. It marked a turning point for the series: Let’s do another take and really run with that.’” And we’re all like, ‘Oh my gosh!’ I remember running up to him like, ‘Steve, keep going with that. Because we had him up on the thing, and it’s just supposed to be this joke of he thinks he’s getting this big honor and he’s so proud and everybody’s laughing at him behind his back, but Steve made this great choice to get very teary-eyed during it. “We just kind of stumbled upon it when we were doing that end scene in ‘Office Olympics’ when they’re giving him the medal. |
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